Supplement
Acetyl-L-carnitine
SaveAn acetylated form of L-carnitine that crosses the blood-brain barrier more readily, studied for cognitive support and mitochondrial function.
Quick verdict
Reasonable evidence in older adults with cognitive decline and in peripheral neuropathy. Benefits in healthy young adults are less clear.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Meta-analyses show modest cognitive improvements in mild cognitive impairment and Alzheimer's populations. Also studied in diabetic neuropathy with positive results on pain scores.
Benefits
- Supports mitochondrial fatty acid transport
- May improve cognitive function in age-related decline
- Studied for nerve pain reduction
Dosage notes
500–2000 mg/day in divided doses. Often taken in the morning due to mild stimulatory effect.
Side effects
- Nausea
- Restlessness
- Fishy body odour at high doses
Who should be cautious
May increase agitation in some individuals. TMAO concerns are theoretically lower than with plain carnitine but not fully resolved.
What this page cannot tell you
Most positive cognitive data are in impaired populations, not healthy young adults.
Leaderboard scores
- Memory55
- Focus50
- Energy48
- Recovery40
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