Amino Acid
Agmatine
SaveA biogenic amine produced by decarboxylation of arginine, acting on imidazoline receptors, NMDA receptors, and nitric oxide pathways. Studied for pain, mood, and neuroprotection.
Quick verdict
Preliminary human evidence for neuropathic pain and mood. Interesting multi-target pharmacology but most data is preclinical.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Small open-label studies suggest benefits for neuropathic pain and as an adjunct in depression. Preclinical data shows NMDA antagonism, NOS inhibition, and imidazoline receptor activation. Randomized controlled trial data is sparse.
Benefits
- Preliminary evidence for neuropathic pain reduction
- Possible mood-enhancing effects as adjunct therapy
- Nitric oxide modulation supporting blood flow
Dosage notes
Typical supplemental range is 500–2000 mg/day in divided doses.
Side effects
- GI discomfort
- Mild hypotension in sensitive individuals
Who should be cautious
May interact with blood-pressure medications. Theoretical interactions with NMDA-active drugs. Not well studied in pregnancy.
What this page cannot tell you
Most human studies are open-label or case series. The multi-target mechanism makes specific claims difficult to validate.
Leaderboard scores
- Pain50
- Mood40
- Muscle25
Write a review
Sign in to write a review.