Supplement
Alpha-ketoglutarate (AKG)
SaveA Krebs-cycle intermediate involved in energy metabolism, amino acid synthesis, and epigenetic regulation, investigated for longevity effects.
Quick verdict
Interesting longevity candidate based on animal studies. Human evidence is early-stage but a large RCT (Rejuvant) has shown biological-age changes.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Mouse lifespan extension reported by the Buck Institute. The Rejuvant trial showed a reduction in biological age markers (DNA methylation clocks) at 1 g/day calcium-AKG over 7 months.
Benefits
- Central metabolite in the Krebs cycle
- Preliminary biological-age reduction data in humans
- Supports collagen and amino acid synthesis
Dosage notes
1000 mg/day of calcium-AKG was used in the Rejuvant trial.
Side effects
- GI discomfort
- Bloating
Who should be cautious
Long-term safety in supplemental doses not fully characterised. May interact with amino acid metabolism.
What this page cannot tell you
Lifespan extension in mice doesn't guarantee human longevity benefits. Biological-age clock changes are surrogate endpoints.
Leaderboard scores
- Longevity50
- Energy38
- Recovery35
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