Peptide
Argireline
SaveAcetyl hexapeptide-3, a cosmetic peptide that inhibits SNARE complex formation to reduce neurotransmitter release at the neuromuscular junction, marketed as a topical alternative to botulinum toxin.
Quick verdict
Modest wrinkle-depth reduction shown in small cosmetic studies. Far less potent than botulinum toxin and limited to surface application.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Several small manufacturer-sponsored trials show 10–30% wrinkle-depth reduction over 30 days. No large independent RCTs.
Benefits
- Mild reduction in expression-line depth
- Non-invasive topical application
- Generally well tolerated on skin
Dosage notes
Used topically at 5–10% concentration in cosmetic serums.
Side effects
- Mild skin irritation
- Contact dermatitis in rare cases
Who should be cautious
Cosmetic use only. Topical penetration is limited. Not a substitute for medical-grade treatments.
What this page cannot tell you
Effect sizes are modest compared to injectable neuromodulators. Most studies are industry-funded.
Leaderboard scores
- Longevity15
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