Supplement
Baicalein
SaveA flavone aglycone from Scutellaria baicalensis (Chinese skullcap) with anti-inflammatory and neuroprotective activity in preclinical models.
Quick verdict
Interesting pharmacology but human data are minimal. Mainly of interest to researchers and those familiar with traditional Chinese formulas.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Demonstrates 12/15-lipoxygenase inhibition, GABAergic modulation, and neuroprotection in rodent models. Human pharmacokinetic data exist but clinical efficacy trials are very limited.
Benefits
- Potent lipoxygenase inhibitor in vitro
- GABAergic anxiolytic potential
- Neuroprotective in animal stroke models
Dosage notes
No established human dose. Preclinical doses translate poorly. Often consumed as part of Scutellaria root extracts at 500–1500 mg.
Side effects
- Possible hepatotoxicity at high doses (case reports with skullcap)
- GI upset
Who should be cautious
Potential herb-drug interactions via CYP modulation. Not well-studied in pregnancy or lactation.
What this page cannot tell you
Most data are in vitro or in rodents. Bioavailability in oral form is moderate and variable.
Leaderboard scores
- Anxiety30
- Focus25
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