Supplement
Baicalin
SaveThe glucuronide conjugate of baicalein from Scutellaria baicalensis, converted to baicalein in the gut. Studied for anti-inflammatory and hepatoprotective properties.
Quick verdict
A prodrug of baicalein with similar preclinical promise and similar lack of robust human trial data.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Gut bacteria convert baicalin to baicalein, the active form. Anti-inflammatory, antiviral, and hepatoprotective effects shown in animal models. Used extensively in traditional Chinese medicine formulas.
Benefits
- Water-soluble prodrug form of baicalein
- Anti-inflammatory in preclinical models
- Long history in traditional Chinese medicine
Dosage notes
Often standardised in Scutellaria extracts; standalone doses of 250–500 mg have been used in research settings.
Side effects
- GI discomfort
- Rare hepatotoxicity (with skullcap products)
Who should be cautious
Same CYP interaction concerns as baicalein. Liver toxicity case reports exist for skullcap products.
What this page cannot tell you
Efficacy depends on gut microbiome composition for conversion. Human clinical data remain limited.
Leaderboard scores
- Immunity30
- Anxiety28
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