Bilobalide

Generally consumed as part of standardised Ginkgo biloba extract rather than in isolation. Individual supplementation is rare and unnecessary.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Demonstrates mitochondrial protection and anti-edema effects in animal brain injury models. Part of the terpene lactone fraction (typically 2.8–3.4% in standard EGb 761 extract). Isolated bilobalide studies in humans are absent.

• Neuroprotective in animal ischaemia models
• Anti-inflammatory in CNS tissue
• Part of well-studied ginkgo extract

Typically consumed via standardised Ginkgo biloba extract (EGb 761) at 120–240 mg/day providing ~3% terpene lactones.

• Bleeding risk (as part of ginkgo)
• Headache
• GI upset

Ginkgo products can increase bleeding risk. Raw ginkgo seeds contain ginkgotoxin (not present in standardised leaf extracts).

Studied only as a component of whole ginkgo extract. Attributing effects specifically to bilobalide vs other ginkgo compounds is difficult.

• Memory32
• Focus30