Carvacrol

Strong antimicrobial properties in vitro, commonly consumed as oregano oil. Human clinical data are limited to small GI-related studies.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Demonstrates broad-spectrum antimicrobial activity (bacteria, fungi, parasites) in vitro. Small human trials on intestinal parasites show some efficacy. Anti-inflammatory via NF-κB inhibition in cell models.

• Broad-spectrum antimicrobial in vitro
• Anti-inflammatory via NF-κB modulation
• Traditional use for GI infections

Typically consumed as oregano oil (60–80% carvacrol): 200–600 mg oregano oil per day in enteric capsules.

• GI burning
• Heartburn
• Mucosal irritation if undiluted

Undiluted oregano oil can burn mucous membranes. May interact with anticoagulants. Not recommended during pregnancy.

In vitro antimicrobial potency rarely translates directly to clinical doses. Most human evidence uses oregano oil, not isolated carvacrol.

• Immunity32