Centrophenoxine

Older clinical data suggests modest cognitive benefits in elderly populations, but modern rigorous trials are lacking.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Studies from the 1970s–80s reported reductions in lipofuscin accumulation and modest memory improvements in elderly subjects. Methodological quality of older trials is poor by modern standards.

• May reduce lipofuscin deposits in aging neurons
• Older studies suggest modest memory improvement in elderly
• Raises brain acetylcholine precursor levels

Common range is 250–750 mg/day in divided doses.

• Nausea
• Headache
• GI discomfort
• Insomnia if taken late

May potentiate cholinergic effects. Avoid concurrent use with anticholinergics or cholinesterase inhibitors without medical supervision.

Evidence base is dated. Modern replication with rigorous methodology is absent.

• Memory40
• Longevity30
• Focus30