Chitosan

Meta-analyses show statistically significant but clinically trivial fat-binding effects. Not a meaningful weight-loss intervention on its own.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Cochrane review found average weight loss of ~1.7 kg over 4 weeks vs placebo—barely clinically relevant. Fat-binding capacity in vivo is much lower than in vitro claims. Minimal effect on lipid panels.

• Binds some dietary fat in the GI tract
• Statistically significant but small weight-loss effect
• May modestly reduce dietary fat absorption

1–3 g before fat-containing meals. Take fat-soluble vitamins and medications at a separate time.

• GI discomfort
• Constipation
• Reduced fat-soluble vitamin absorption

Shellfish allergy is a contraindication. May reduce absorption of fat-soluble vitamins and medications.

The theoretical fat-binding mechanism is real but the in vivo effect is small. Marketing greatly overstates efficacy.

• Weight loss22