Chlorogenic acid

Mild glucose-moderating effects are supported. Weight-loss claims from green coffee bean extract are overhyped relative to the modest data.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Inhibits glucose-6-phosphatase and delays glucose absorption. Meta-analyses of green coffee bean extract show small weight-loss effects (~2 kg over 12 weeks). The retracted Vinson et al. study inflated early enthusiasm.

• Modulates post-prandial glucose response
• Antioxidant polyphenol
• May support modest weight management

200–400 mg of chlorogenic acid per day, typically from green coffee bean extract standardised to 45–50% chlorogenic acids.

• GI discomfort
• Caffeine-related effects if from green coffee
• Headache

Contains some caffeine when sourced from green coffee. The FTC required retraction of misleading weight-loss claims for green coffee bean extract.

The retracted Vinson study was central to marketing claims. Remaining evidence supports only modest metabolic effects.

• Weight loss28
• Energy25