Supplement
Cordycepin
Save3'-deoxyadenosine, the principal bioactive nucleoside from Cordyceps militaris, with anti-inflammatory and potential anti-tumour activity in preclinical models.
Quick verdict
Interesting pharmacology as an adenosine analogue, but human clinical data are very limited. Most cordyceps supplement benefits may involve other compounds too.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Inhibits polyadenylation and activates AMPK in cell models. Anti-inflammatory and antitumour effects in rodents. Human pharmacokinetic data are minimal. Rapidly deaminated by adenosine deaminase in vivo.
Benefits
- AMPK activator in vitro
- Anti-inflammatory adenosine analogue
- Part of the pharmacology of Cordyceps mushrooms
Dosage notes
No isolated cordycepin dose established. Typically consumed via Cordyceps militaris extract (1–3 g/day) providing variable cordycepin content.
Side effects
- GI discomfort
- Dry mouth
- Unknown long-term effects of isolated compound
Who should be cautious
Rapid enzymatic degradation limits oral bioavailability. Quality of cordyceps products varies enormously.
What this page cannot tell you
Attributing cordyceps supplement effects specifically to cordycepin is difficult. Bioavailability is a major limitation.
Leaderboard scores
- Energy30
- Immunity28
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