Supplement
DIM
SaveDiindolylmethane, a metabolite of indole-3-carbinol from cruciferous vegetables, studied for oestrogen metabolism modulation and hormonal balance.
Quick verdict
May favourably shift oestrogen metabolite ratios (2-OH:16α-OH). Evidence is preliminary but mechanistically plausible. Used in functional medicine for hormonal support.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Shifts oestrogen metabolism toward 2-hydroxyestrone (considered less proliferative) in some studies. Small RCTs in cervical dysplasia showed mixed results. Absorption requires formulation enhancement (microencapsulated forms).
Benefits
- May shift oestrogen metabolism toward favourable metabolites
- Derived from cruciferous vegetable compounds
- Mechanistically plausible hormonal modulation
Dosage notes
100–200 mg/day of bioavailable DIM (microencapsulated). Standard crystalline DIM has poor absorption.
Side effects
- Dark urine
- Headache
- GI upset
- Possible hormonal changes
Who should be cautious
May alter hormone levels—not appropriate during pregnancy or in hormone-sensitive cancers without oncologist guidance. Can change urine colour.
What this page cannot tell you
Oestrogen metabolite ratios as a health endpoint are not fully validated. Clinical outcome data are limited.
Leaderboard scores
- Mood25
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