Dimethylglycine

Theoretical metabolic roles are real but clinical supplementation data are scant and unconvincing. A solution in search of a problem for most people.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Acts as a methyl donor in one-carbon metabolism. A few small, old studies suggested immune and exercise benefits, but none have been convincingly replicated. The body produces it endogenously.

• Methyl donor in one-carbon metabolism
• Theoretically supports immune cell function
• Well-tolerated

125–500 mg/day is commonly used. No established clinical dose.

• Rare reports of hyperactivity or insomnia
• GI discomfort (uncommon)

Generally regarded as safe at supplement doses. No significant safety concerns documented.

Endogenous production means supplementation may be redundant. Evidence base is extremely thin.

• Immunity18
• Energy15