Diosmin

One of the few flavonoids with pharmaceutical-grade evidence. Effective for venous insufficiency and haemorrhoids. Underappreciated outside of European medicine.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Daflon 500 (micronised diosmin/hesperidin) is a prescription venotonic in many European countries. Meta-analyses support efficacy for chronic venous disease symptoms and haemorrhoid flare reduction. Micronisation is critical for oral absorption.

• Reduces venous insufficiency symptoms
• Shortens haemorrhoid flare duration
• Pharmaceutical-grade evidence in Europe

500 mg twice daily (often as micronised diosmin 450 mg + hesperidin 50 mg). Micronised form is essential.

• Mild GI discomfort
• Headache (uncommon)
• Skin rash (rare)

Standard non-micronised diosmin has poor bioavailability. Ensure product is micronised. GI side effects are mild.

Benefit is specific to venous pathology. General 'antioxidant' marketing extends beyond the evidence.

• Pain45
• Recovery38