Supplement
DMAE
SaveDimethylaminoethanol, a choline precursor and potential acetylcholine modulator, historically investigated for cognitive function and skin firmness.
Quick verdict
Weak and dated clinical evidence for cognitive benefits. Topical skin-firming data are slightly more promising than oral cognitive data. Not a first-choice nootropic.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
1970s studies in hyperkinetic children showed mixed results. One study in elderly showed possible EEG changes. Mechanism may involve membrane phosphatidylethanolamine stabilisation rather than direct acetylcholine increase. Topical DMAE has firming effects in dermatology studies.
Benefits
- May stabilise cell membranes
- Topical skin-firming effects in dermatology studies
- Historical nootropic interest
Dosage notes
100–300 mg/day orally. Topical creams use 3% DMAE.
Side effects
- Insomnia
- Headache
- Muscle tension
- Possible teratogenicity (avoid in pregnancy)
Who should be cautious
May worsen symptoms in bipolar disorder or seizure disorders. Historical teratogenicity concern (one animal study).
What this page cannot tell you
The acetylcholine-boosting mechanism is questioned; DMAE may actually inhibit choline uptake in some models. Evidence is old and unreplicated.
Leaderboard scores
- Focus22
- Memory20
Write a review
Sign in to write a review.