Supplement
Evodiamine
SaveAn indoloquinazoline alkaloid from Evodia rutaecarpa with thermogenic, anti-inflammatory, and potential anti-obesity activity in preclinical models.
Quick verdict
Interesting thermogenic and vanilloid-receptor activity in cell and animal models. Essentially no human clinical data exist. Experimental.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Activates TRPV1 receptors (similar to capsaicin), inhibits adipogenesis in cell models, and shows anti-tumour properties in rodents. No published human efficacy or pharmacokinetic trials.
Benefits
- TRPV1 activation for thermogenesis (preclinical)
- Anti-adipogenic in cell models
- Part of traditional Evodia preparations
Dosage notes
No established human dose. Supplement products typically offer 10–30 mg, with no clinical basis.
Side effects
- Unknown in humans
- Theoretical GI irritation from TRPV1 activation
Who should be cautious
Safety profile in humans is uncharacterised. May interact with CYP enzymes based on in vitro data.
What this page cannot tell you
All claims derive from cell and animal studies. Oral bioavailability in humans is unknown.
Leaderboard scores
- Weight loss15
- Energy12
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