Feverfew

Worth considering for migraine prevention, though responses are mixed and standardized extracts matter.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Clinical data for migraine prevention is mixed but credible enough that feverfew remains one of the more established headache herbs. Parthenolide content is often used for standardization.

• May reduce migraine frequency in some users
• Shows anti-inflammatory platelet and prostaglandin effects
• Long history of headache-focused use

Often used as 50-150 mg/day of standardized extract rather than fresh leaf.

• Mouth ulcers from fresh leaf
• GI upset
• Possible rebound symptoms if stopped abruptly

Avoid in pregnancy and around surgery because of bleeding concerns. Fresh leaf can irritate the mouth significantly.

Migraine benefit is more about prevention than acute relief, and not every extract replicates the better trials.

• Pain45