Peptide
Ghrelin
SaveA 28-amino-acid endogenous peptide hormone produced primarily by the stomach that stimulates appetite, GH release, and gastric motility.
Quick verdict
Well-characterized endogenous hormone with clinical trials for cachexia and gastroparesis. Therapeutic use is limited by short half-life and appetite-stimulating effects.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Multiple human studies confirm orexigenic and GH-releasing effects. Clinical trials in cancer cachexia and gastroparesis show moderate efficacy. Synthetic analogs are in development.
Benefits
- Appetite stimulation in cachexia and wasting syndromes
- GH release confirmed in human studies
- Gastric motility improvement in gastroparesis trials
Dosage notes
Research studies: 1–5 mcg/kg IV. Clinical use requires medical supervision.
Side effects
- Increased appetite and hunger
- Transient hyperglycemia
- Flushing
- GI discomfort
Who should be cautious
Potent appetite stimulant. Not suitable for weight management. Short half-life requires frequent dosing.
What this page cannot tell you
Therapeutic utility is limited to conditions where appetite/GH stimulation is desired. Not a general-purpose peptide.
Leaderboard scores
- Muscle30
- Recovery25
- Energy20
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