Glutathione

Essential endogenous antioxidant, but oral supplementation has bioavailability challenges. Liposomal and sublingual forms show more promise than standard oral glutathione.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Intravenous glutathione reliably raises tissue levels. Oral reduced glutathione at 1000 mg/day showed some increase in blood levels in a small RCT. Liposomal glutathione appears to have better bioavailability. Raising glutathione via precursors (NAC, glycine, cysteine) may be more effective.

• Master antioxidant protecting cells from oxidative damage
• Critical for phase II liver detoxification
• Supports immune cell function, particularly lymphocytes

Oral reduced glutathione: 250-1000 mg daily. Liposomal forms may be effective at lower doses. NAC (600-1800 mg) is an alternative precursor strategy.

• Generally well-tolerated
• Mild GI discomfort
• Bloating at higher doses

May interact with chemotherapy drugs. IV administration should only be done under medical supervision.

Standard oral glutathione is largely degraded in the GI tract. Liposomal formulations or precursor strategies (NAC, whey protein) may be more practical.

• Longevity50
• Immunity45