Peptide
HCG
SaveHuman chorionic gonadotropin, a glycoprotein hormone that mimics LH, FDA-approved for fertility treatment and widely used off-label to support testosterone therapy.
Quick verdict
Well-established pharmaceutical with decades of clinical use. FDA-approved for hypogonadotropic hypogonadism and fertility. Effective for maintaining testicular function during TRT.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Extensive clinical literature for fertility and hypogonadism. Off-label TRT adjunct use is well supported by clinical practice and smaller trials.
Benefits
- Maintains testicular function and size during TRT
- FDA-approved for male and female infertility
- Preserves intratesticular testosterone production
Dosage notes
Fertility: 1000–10000 IU IM per protocol. TRT adjunct: 250–500 IU subcutaneously 2–3 times weekly.
Side effects
- Estradiol elevation
- Injection-site pain
- Headache
- Gynecomastia risk
- Ovarian hyperstimulation in women
Who should be cautious
Prescription-only. Can elevate estradiol significantly. FDA warning against use as a weight-loss agent.
What this page cannot tell you
Off-label uses (TRT support, weight loss) vary in evidence quality. Estrogen management may be needed.
Leaderboard scores
- Libido50
- Muscle25
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