Peptide
Hexarelin
SaveA synthetic hexapeptide growth-hormone secretagogue that acts on the ghrelin receptor, notable for potent GH release and documented cardiac effects.
Quick verdict
Among the most potent GHRPs. Notable for cardioprotective properties in preclinical studies. GH response desensitizes with chronic use.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Human studies confirm potent GH release but show tachyphylaxis with repeated dosing. Cardioprotective effects demonstrated in vitro and animal models.
Benefits
- Potent acute GH secretagogue effect
- Cardioprotective properties in preclinical models
- Well-characterized in human pharmacology studies
Dosage notes
Typical: 100–200 mcg subcutaneously. Cycling is recommended to avoid desensitization.
Side effects
- Elevated cortisol and prolactin
- Water retention
- Desensitization with chronic use
- Injection-site reactions
Who should be cautious
Not FDA-approved. GH response diminishes with chronic use. Raises cortisol and prolactin.
What this page cannot tell you
Desensitization limits chronic use. Cardiac benefits are preclinical only.
Leaderboard scores
- Muscle38
- Recovery25
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