Peptide
Humanin
SaveA 24-amino-acid mitochondrial-derived peptide (MDP) with cytoprotective effects against Alzheimer's-related toxicity, oxidative stress, and apoptosis.
Quick verdict
Fascinating basic science implicating it in cellular stress protection and aging. Entirely preclinical with no human therapeutic trials.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Extensive cell-culture and animal data on neuroprotection and metabolic effects. Circulating levels correlate with longevity in epidemiological studies. No therapeutic trials.
Benefits
- Neuroprotective against amyloid-beta toxicity in vitro
- Metabolic protection in animal diabetes models
- Epidemiological association with longevity
Dosage notes
No human dosing established. Research use only.
Side effects
- Unknown in humans
- Theoretical pro-survival effects on damaged cells
Who should be cautious
Not available as a therapeutic. Research reagent only. Theoretical concerns about promoting survival of damaged cells.
What this page cannot tell you
All data are preclinical or epidemiological. Translation to human therapy is entirely speculative.
Leaderboard scores
- Longevity25
- Memory15
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