Hydroxytyrosol

EFSA-approved health claim for cardiovascular protection from olive oil polyphenols. Isolated supplementation data is growing but still limited compared to dietary olive oil studies.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

EFSA authorized a health claim that olive oil polyphenols (including hydroxytyrosol) protect LDL from oxidative damage at 5 mg/day. Studies show anti-inflammatory, anti-atherogenic, and neuroprotective effects. Most evidence comes from olive oil consumption rather than isolated supplementation.

• Protects LDL cholesterol from oxidation (EFSA-approved claim)
• Potent antioxidant and anti-inflammatory
• May support cardiovascular and brain health

EFSA recommends at least 5 mg hydroxytyrosol daily from olive oil. Supplements typically provide 5-25 mg daily.

• Generally well-tolerated
• Mild GI effects at higher doses

May lower blood pressure; caution with antihypertensives. May interact with diabetes medications.

Strongest evidence is for dietary olive oil consumption. Isolated hydroxytyrosol supplements have fewer clinical trials. Bioavailability varies by formulation.

• Longevity55
• Immunity35