Hyperforin

Well-established antidepressant mechanism, but typically consumed as part of St. John's Wort extract. Known for significant drug interactions via CYP3A4 induction.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Hyperforin activates TRPC6 channels and broadly inhibits monoamine reuptake. St. John's Wort extracts standardized to hyperforin are effective for mild-to-moderate depression in multiple meta-analyses. However, hyperforin is the main driver of CYP3A4/PXR activation causing serious drug interactions.

• Broad monoamine reuptake inhibition for antidepressant effects
• Effective for mild-to-moderate depression in meta-analyses
• Anti-inflammatory properties via NF-kB modulation

St. John's Wort extracts typically standardized to 3-5% hyperforin, dosed at 300 mg extract three times daily.

• Photosensitivity
• GI discomfort
• Serious drug interactions via CYP3A4 induction
• Insomnia or vivid dreams

Major CYP3A4 inducer; contraindicated with oral contraceptives, HIV antiretrovirals, warfarin, cyclosporine, and many other drugs. May cause photosensitivity.

Inseparable from drug interaction concerns. Low-hyperforin extracts may reduce interaction risk but also reduce efficacy. Not a substitute for professional mental health treatment.

• Mood62
• Anxiety45
• Stress40