Hypericin

Less relevant for antidepressant effects than hyperforin, but studied for antiviral and photodynamic therapy applications. Primarily a marker compound in St. John's Wort standardization.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Hypericin was initially believed to be the antidepressant component of St. John's Wort, but hyperforin is now considered primary. Hypericin has demonstrated antiviral activity against enveloped viruses in vitro and is being investigated for photodynamic cancer therapy. It is a potent photosensitizer.

• Antiviral activity against enveloped viruses in vitro
• Potential photodynamic therapy agent for cancer research
• Marker compound for St. John's Wort quality control

Not typically dosed independently. St. John's Wort extracts are often standardized to 0.3% hypericin as a quality marker.

• Photosensitivity (primary concern)
• Skin rash with sun exposure
• GI discomfort

Strong photosensitizer; avoid sun exposure at high doses. Same drug interaction concerns as St. John's Wort overall.

Most antidepressant activity now attributed to hyperforin, not hypericin. Antiviral and anticancer applications are experimental.

• Mood25
• Immunity20