Supplement
Idebenone
SaveA synthetic analogue of CoQ10 with superior ability to function under low-oxygen conditions. Used as a prescription drug for mitochondrial disorders in some countries.
Quick verdict
Approved in Europe for Leber hereditary optic neuropathy. As a general supplement, evidence for cognitive or anti-aging benefits is limited to small or preclinical studies.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Idebenone transfers electrons in the mitochondrial chain even under low-oxygen conditions where CoQ10 fails. EU-approved for LHON (Raxone). Small studies suggest cognitive and skin benefits. It does not inhibit Complex I like CoQ10, which may be advantageous in some mitochondrial disorders.
Benefits
- Functions as an electron carrier under low-oxygen conditions
- EU-approved for Leber hereditary optic neuropathy
- Potent antioxidant with better solubility than CoQ10
Dosage notes
Supplement doses typically range from 45-150 mg daily. Prescription doses for LHON are 900 mg daily.
Side effects
- GI discomfort
- Insomnia
- Mild headache
Who should be cautious
Prescription drug in some jurisdictions. May interact with anticoagulants. Limited long-term safety data as a supplement.
What this page cannot tell you
Strongest evidence is for specific mitochondrial diseases, not general supplementation. Cognitive and anti-aging claims are based on limited data.
Leaderboard scores
- Longevity38
- Energy35
- Focus28
- Memory25
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