Peptide
Irisin
SaveA myokine cleaved from fibronectin type III domain-containing protein 5 (FNDC5), released during exercise and proposed to mediate browning of white adipose tissue.
Quick verdict
Intriguing exercise-mimetic concept but exogenous therapeutic use is entirely preclinical. Its role as a circulating hormone is still debated.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Initial 2012 discovery generated excitement. Subsequent controversy about detection methods and true circulating levels. Preclinical data on fat browning are inconsistent.
Benefits
- Exercise-mediated adipose browning proposed in animal models
- Possible bone-health effects in preclinical data
Dosage notes
No human dosing established. Research use only.
Side effects
- Unknown in humans
Who should be cautious
Not available as a therapeutic. Assay reliability for measuring irisin is debated.
What this page cannot tell you
The irisin field has been marked by controversy over detection methods. Translation to therapy is speculative.
Leaderboard scores
- Weight loss15
- Energy10
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