Supplement
Iron Bisglycinate
SaveA chelated form of iron bound to two glycine molecules, offering superior absorption and significantly fewer GI side effects compared to ferrous sulfate.
Quick verdict
Well-supported as a better-tolerated alternative to standard iron salts. Comparable or superior efficacy for correcting deficiency with fewer side effects.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Multiple comparative trials show iron bisglycinate achieves similar or better iron status improvement as ferrous sulfate at lower elemental iron doses, with significantly less GI distress. The chelated form resists interactions with phytates and other absorption inhibitors. Particularly useful in populations with GI sensitivity.
Benefits
- Better GI tolerability than ferrous sulfate
- Higher bioavailability at lower doses
- Less affected by dietary absorption inhibitors
Dosage notes
Typically 20-25 mg elemental iron from bisglycinate can achieve similar effects to 50-65 mg from ferrous sulfate. Dose based on deficiency severity.
Side effects
- Significantly fewer GI effects than ferrous sulfate
- Mild constipation possible
- Dark stools
Who should be cautious
Same general iron supplementation cautions apply. Do not use without documented deficiency.
What this page cannot tell you
More expensive than ferrous sulfate. While better tolerated, it is still iron supplementation and requires monitoring.
Leaderboard scores
- Energy65
- Focus40
- Immunity35
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