Peptide
KPV
SaveA C-terminal tripeptide fragment (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone (alpha-MSH) with anti-inflammatory properties.
Quick verdict
Preclinical data support anti-inflammatory activity in colitis and skin inflammation models. No human clinical trials published.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Animal studies show reduced intestinal inflammation and skin inflammation. Mechanism involves NF-kB pathway inhibition. No human trials.
Benefits
- Anti-inflammatory activity in colitis animal models
- NF-kB pathway modulation demonstrated in vitro
- Lacks melanogenic side effects of full alpha-MSH
Dosage notes
No validated human dosing. Community protocols vary widely.
Side effects
- Unknown in humans
- Theoretical immunosuppression
Who should be cautious
Not approved for any use. Gray-market products for oral or topical use are not validated.
What this page cannot tell you
All data are preclinical. Oral bioavailability and systemic effects in humans are unknown.
Leaderboard scores
- Immunity20
- Pain15
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