Amino Acid
L-Tyrosine
SaveA non-essential amino acid and precursor to dopamine, norepinephrine, and epinephrine. Studied for cognitive performance under stress, sleep deprivation, and cold exposure.
Quick verdict
Consistent evidence for preserving cognitive performance under acute stress conditions. Benefits in non-stressed states are much less clear.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Military and laboratory studies show tyrosine supplementation preserves working memory, cognitive flexibility, and mood during cold stress, sleep deprivation, and multitasking. Effects in rested, non-stressed individuals are minimal, consistent with the rate-limiting step being relevant only when catecholamine demand is high.
Benefits
- Preserves cognitive function under acute stress
- Supports catecholamine synthesis during high demand
- May help maintain mood during sleep deprivation
Dosage notes
500–2000 mg taken 30–60 minutes before a stressful task or demanding cognitive work.
Side effects
- Headache at high doses
- GI discomfort
- Insomnia if taken late
Who should be cautious
Avoid combining with MAOIs. Caution with thyroid disorders (tyrosine is a thyroid hormone precursor). Theoretical interaction with L-DOPA.
What this page cannot tell you
Benefits are specific to high-demand or stress conditions. Everyday cognitive enhancement in non-stressed individuals is not well supported.
Leaderboard scores
- Focus65
- Stress60
- Energy45
- Mood40
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