Supplement
Limonene
SaveA monoterpene found abundantly in citrus peel oils. Studied for GI benefits, including gastroesophageal reflux, and for potential chemopreventive properties.
Quick verdict
Some evidence for GERD symptom relief and interesting preclinical cancer data, but human clinical trials are limited and small.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
D-limonene has shown gastroprotective effects, possibly by promoting peristalsis and gastric acid neutralization. A small trial found relief of GERD symptoms. Animal studies show chemopreventive activity in breast and colon cancer models. Phase I cancer trials used high doses (up to 8 g/m2/day).
Benefits
- May relieve GERD symptoms in some individuals
- Gastroprotective effects in animal models
- Chemopreventive properties in preclinical research
Dosage notes
For GERD: 1000 mg every other day for 20 days has been used in limited trials. General supplementation: 500-1000 mg daily.
Side effects
- GI discomfort or heartburn
- Belching with citrus taste
- Diarrhea at high doses
Who should be cautious
May cause heartburn in some individuals despite GERD claims. High doses can cause GI irritation. Contact sensitization risk with concentrated topical forms.
What this page cannot tell you
GERD evidence is from a single small trial. Cancer prevention data is preclinical or early-phase only. Dual use as a solvent complicates product quality.
Leaderboard scores
- Recovery20
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