Lysine

Moderate evidence for reducing herpes simplex recurrence frequency. Otherwise an essential amino acid with importance primarily when dietary intake is inadequate.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Lysine competes with arginine for absorption and may reduce HSV replication by lowering intracellular arginine. Several older trials show reduced HSV recurrence at 1-3 g/day, though study quality is variable. Also important for collagen synthesis, carnitine production, and calcium absorption.

• May reduce frequency and severity of herpes simplex outbreaks
• Essential for collagen synthesis and tissue repair
• Supports calcium absorption and carnitine production

For HSV prevention: 1000-3000 mg daily. General supplementation: 500-1000 mg daily. Best taken on empty stomach away from arginine-rich foods.

• GI discomfort at high doses
• Nausea
• Diarrhea
• Abdominal cramps

High doses may increase calcium absorption excessively. Theoretical concern about increased cholesterol via carnitine pathway. Avoid in those with hyperlysinemia.

HSV evidence is based on older trials of moderate quality. Benefits for cold sores are modest and not universal. Most people consuming adequate protein are not lysine-deficient.

• Immunity40
• Recovery30