Supplement
Matrine
SaveAn alkaloid from Sophora flavescens root used in traditional Chinese medicine. Studied for anti-inflammatory, antiviral, and potential anti-tumor properties, primarily in preclinical settings.
Quick verdict
Interesting preclinical pharmacology but very limited Western clinical data. Used in Chinese hospitals as an injection for hepatitis and certain cancers.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Matrine and oxymatrine have shown anti-HBV activity, anti-fibrotic effects in liver disease, and anti-tumor activity in multiple cancer cell lines. Injectable forms are used clinically in China for hepatitis B and as adjuvant cancer therapy. Western clinical trials are scarce.
Benefits
- Anti-HBV activity demonstrated clinically in Chinese trials
- Anti-inflammatory and anti-fibrotic in liver disease models
- Preclinical anti-tumor activity
Dosage notes
No established Western supplemental dose. Chinese clinical use involves injection or standardized oral forms under medical supervision.
Side effects
- Potential hepatotoxicity
- Dizziness
- GI discomfort
- Allergic reactions
Who should be cautious
Potential hepatotoxicity at high doses. Narrow therapeutic window. Quality control of supplements is a concern. Not recommended without medical supervision.
What this page cannot tell you
Most clinical evidence is from Chinese-language publications and may not meet Western trial quality standards. Oral supplement bioavailability and dosing are poorly characterized.
Leaderboard scores
- Immunity22
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