Peptide
MIF-1
SaveMelanocyte-stimulating hormone release-inhibiting factor (Pro-Leu-Gly-NH2), a small endogenous peptide with anti-opiate and antidepressant properties in early studies.
Quick verdict
Studied in the 1970s–90s for depression and opiate withdrawal. Results were modest and research interest faded. Not developed commercially.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Small clinical studies from the 1970s–90s showed modest antidepressant and anti-opiate effects. Research did not progress to modern clinical development.
Benefits
- Modest antidepressant effects in early human studies
- Anti-opiate withdrawal activity reported
- Crosses the blood-brain barrier
Dosage notes
Historical trials used 10–60 mg IV or oral. No current clinical protocols.
Side effects
- Minimal side effects reported in historical studies
- Headache
Who should be cautious
Not commercially available. Historical research compound only.
What this page cannot tell you
Data are decades old and methodologically dated by modern standards.
Leaderboard scores
- Mood20
- Pain15
Write a review
Sign in to write a review.