Peptide
MOTS-c
SaveA mitochondrial-derived peptide encoded in the 12S rRNA gene, proposed as an exercise mimetic with effects on AMPK activation and metabolic regulation.
Quick verdict
Exciting preclinical data as an exercise and metabolic mimetic. Human studies are beginning but no therapeutic product exists.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Rodent studies show improved glucose homeostasis, exercise capacity, and lifespan effects. A small human pharmacokinetic study has been completed. Circulating levels decline with age.
Benefits
- AMPK activation and improved insulin sensitivity in mice
- Exercise-mimetic effects in aged mouse models
- Circulating levels correlate with metabolic health in observational data
Dosage notes
No validated human dosing. Rodent studies use 5–15 mg/kg IP. Community protocols cite 5–10 mg subcutaneously weekly.
Side effects
- Unknown in humans
- Injection-site reactions
Who should be cautious
Not approved for any use. Injectable products from gray-market sources are unvalidated.
What this page cannot tell you
Primarily rodent data. The human PK study did not evaluate efficacy endpoints.
Leaderboard scores
- Longevity30
- Energy25
- Weight loss20
Write a review
Sign in to write a review.