Peptide
Neurotrophin-3
SaveA neurotrophic factor (NT-3) that supports survival and differentiation of neurons, particularly proprioceptive sensory neurons and motor neurons.
Quick verdict
Well-characterized neurotrophic factor in basic neuroscience. Clinical development has been limited by delivery challenges across the blood-brain barrier.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Extensive preclinical data on neuronal survival and regeneration. Small clinical trials for neuropathy. Delivery remains a major pharmacological challenge.
Benefits
- Supports neuronal survival and differentiation preclinically
- Potential for peripheral neuropathy treatment
- Well-studied neurotrophic signaling biology
Dosage notes
Clinical trials used subcutaneous injections at varying doses. No standard therapeutic protocol.
Side effects
- Injection-site reactions
- Paresthesias
- Cough reported in trials
Who should be cautious
Not commercially available as a therapeutic. BBB penetration is poor with systemic administration.
What this page cannot tell you
Strong preclinical rationale but clinical translation has been hampered by pharmacokinetic limitations.
Leaderboard scores
- Recovery20
- Pain18
Write a review
Sign in to write a review.