Nobiletin

Exciting preclinical data for circadian rhythm modulation and metabolic health, but human clinical data is essentially absent. A compound to watch in longevity research.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Nobiletin enhances circadian clock amplitude via ROR activation and prevents metabolic syndrome in high-fat-diet mice even without caloric restriction. It also shows anti-inflammatory, neuroprotective, and anti-tumor activity in preclinical models. Bioavailability is moderate and may be enhanced by other citrus flavonoids.

• Enhances circadian clock amplitude in preclinical models
• Prevents metabolic syndrome in animal studies
• Anti-inflammatory and neuroprotective properties

No established human dose. Animal studies use doses roughly equivalent to 200-500 mg in humans. Citrus peel extracts standardized to nobiletin are available.

• Limited safety data
• Mild GI effects expected
• Unknown long-term profile

Very limited human safety data. May interact with CYP enzymes. Concentrated supplemental forms are relatively new to market.

Animal data is impressive but human translation is entirely unproven. Oral bioavailability and optimal dosing in humans are unknown.

• Longevity28
• Sleep22