Oxaloacetate

Interesting caloric restriction mimetic mechanism, but human evidence is very preliminary. One small trial showed reduced brain glutamate levels. An early-stage longevity compound.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Oxaloacetate supplementation shifts the cytoplasmic NAD+/NADH ratio, mimicking aspects of caloric restriction. Animal studies show lifespan extension in C. elegans. One small human trial found it reduced brain glutamate levels (measured by MRS). Thermally stabilized forms (as benaGene or enOXA) are required for oral supplementation.

• Caloric restriction mimetic via NAD+/NADH ratio modulation
• May reduce brain glutamate levels
• Krebs cycle intermediate supporting energy metabolism

Typical supplement doses: 100-200 mg thermally stabilized oxaloacetate daily. Must be in stabilized form as raw oxaloacetate degrades rapidly.

• Limited safety data
• GI discomfort
• Hunger or fatigue (CR mimetic effects)

Very limited human safety data. Chemically unstable; requires specific stabilization. Expensive.

Animal lifespan data is in simple organisms only. The single human brain study was very small. Caloric restriction mimicry is theoretical and unproven to extend human lifespan. Very early-stage research.

• Longevity25
• Energy20