Peptide
P21
SaveA synthetic peptide derived from ciliary neurotrophic factor (CNTF) that promotes neurogenesis by inhibiting leukemia inhibitory factor signaling, studied for cognitive enhancement.
Quick verdict
Preclinical data in Alzheimer's mouse models show increased neurogenesis and reduced tau pathology. No human clinical trials exist.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Mouse studies from a single group show improved memory and neurogenesis. Mechanism involves LIF receptor antagonism. No human data.
Benefits
- Increased neurogenesis in Alzheimer's mouse models
- Reduced tau hyperphosphorylation in mice
- Novel mechanism distinct from cholinesterase inhibitors
Dosage notes
No validated human dosing. Mouse studies use 50 mcg/day IP.
Side effects
- Unknown in humans
- Injection-site reactions possible
Who should be cautious
Not approved for any use. No human safety data. Gray-market products are unverified.
What this page cannot tell you
All data from a single research group in mouse models. Human translation is speculative.
Leaderboard scores
- Memory20
- Focus15
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