Peptide
PAL-GHK (Palmitoyl Tripeptide-1)
SaveA lipophilic derivative of the GHK peptide (palmitoyl tripeptide-1) designed for improved skin penetration, widely used in anti-aging cosmetic formulations.
Quick verdict
Popular cosmetic active ingredient. The palmitoyl modification improves skin absorption. Clinical evidence is mostly manufacturer-sponsored.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
In-vitro and small clinical studies show collagen stimulation and wrinkle reduction. Often paired with palmitoyl tetrapeptide-7 (Matrixyl 3000). Independent data are limited.
Benefits
- Improved skin penetration over GHK alone
- Collagen stimulation in vitro and small clinical studies
- Widely available in commercial skincare products
Dosage notes
Topical use in cosmetic serums and creams at proprietary concentrations.
Side effects
- Mild skin irritation possible
- Contact dermatitis in sensitive skin
Who should be cautious
Cosmetic ingredient only. Not a drug. Efficacy claims may be overstated by manufacturers.
What this page cannot tell you
Evidence is primarily from cosmetic industry studies. Independent academic replication is sparse.
Leaderboard scores
- Longevity15
Write a review
Sign in to write a review.