Supplement
Parthenolide
SaveParthenolide is the primary bioactive sesquiterpene lactone in feverfew, studied for migraine prevention and anti-inflammatory activity.
Quick verdict
Modest evidence for migraine prophylaxis; anti-inflammatory potential is mainly preclinical.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Several small RCTs support feverfew (standardized to parthenolide) for migraine frequency reduction. NF-kB inhibition is well-documented in vitro.
Benefits
- May reduce migraine frequency
- Inhibits NF-kB inflammatory signaling
- Potential anti-cancer research interest
Dosage notes
Typically 0.2–0.6 mg parthenolide daily from standardized feverfew extract.
Side effects
- Mouth ulcers from chewing leaves
- GI upset
- Rebound headaches on discontinuation
Who should be cautious
Not recommended during pregnancy. May increase bleeding risk with anticoagulants.
What this page cannot tell you
Most clinical trials used whole feverfew extracts, making it hard to isolate parthenolide-specific effects.
Leaderboard scores
- Pain45
- Immunity30
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