Nootropic
Phenibut
SaveA synthetic GABA analog (beta-phenyl-GABA) that crosses the blood-brain barrier and acts on GABA-B receptors. Developed in Russia and used there as an anxiolytic since the 1960s.
Quick verdict
Effective anxiolytic but carries significant dependence and withdrawal risks. Tolerance develops rapidly, and withdrawal can be severe and medically dangerous.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Approved in Russia for anxiety, insomnia, and vestibular disorders. Acts primarily on GABA-B receptors (similar to baclofen) with additional effects on voltage-gated calcium channels. Western case reports of dependence and severe withdrawal are increasing.
Benefits
- Potent anxiolytic effect
- May improve sleep quality acutely
- Crosses blood-brain barrier unlike GABA itself
Dosage notes
Russian prescribing: 250–1000 mg/day. Community consensus is to limit use to 1–2 times per week maximum to avoid dependence.
Side effects
- Dependence with regular use
- Severe withdrawal syndrome
- Drowsiness
- Nausea
- Tolerance
Who should be cautious
High dependence potential with daily use. Withdrawal can include seizures, psychosis, and rebound anxiety. Should not be combined with alcohol or other GABAergics. Not approved for medical use in most Western countries.
What this page cannot tell you
Anxiolytic effect is real but risk-benefit ratio is unfavorable for chronic use. Tolerance develops within days of daily dosing.
Leaderboard scores
- Anxiety75
- Sleep65
- Stress60
- Mood50
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