Supplement
Phloretin
SavePhloretin is a dihydrochalcone flavonoid found in apple skin with antioxidant and glucose transporter–inhibiting properties.
Quick verdict
Interesting preclinical profile for metabolic health and skin protection; human data is very limited.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
In-vitro studies show GLUT2 inhibition, antioxidant activity, and anti-glycation effects. No significant human clinical trials exist.
Benefits
- Potent antioxidant activity in vitro
- May inhibit glucose absorption
- Skin-protective properties in topical applications
Dosage notes
No established oral dosage. Topical products typically contain 2% phloretin.
Side effects
- Insufficient human data to characterize
- Potential skin irritation with topical use
Who should be cautious
Low bioavailability when taken orally. Safety profile in supplemental doses not well characterized.
What this page cannot tell you
Most research is cell-culture or animal-based. Topical use in dermatology is better studied than oral supplementation.
Leaderboard scores
- Longevity25
- Weight loss20
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