Picamilon

Combines cerebral vasodilation (niacin) with GABAergic calming. Used medically in Russia but removed from US supplement market by FDA in 2015.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Russian clinical use for migraine, cerebrovascular insufficiency, and anxiety disorders. The niacin moiety provides cerebral vasodilation while released GABA provides anxiolytic effects. FDA determined it does not qualify as a dietary supplement in the US.

• Dual mechanism: cerebral vasodilation plus GABAergic calming
• Crosses blood-brain barrier unlike oral GABA alone
• Used clinically in Russia for anxiety and cerebrovascular disorders

Russian prescribing: 50–200 mg two to three times daily.

• Niacin flush (less common than pure niacin)
• Hypotension
• Headache
• Drowsiness

FDA removed from US market (not recognized as a supplement). Quality varies by source. GABAergic interactions possible.

Most evidence is from Russian medical practice. Regulatory status varies globally.

• Anxiety45
• Stress40
• Focus25