Piperine

Excellent bioavailability enhancer with robust pharmacokinetic evidence. Stand-alone health benefits are secondary.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Well-documented enhancement of curcumin bioavailability (up to 2000%). Also improves absorption of CoQ10, resveratrol, and certain drugs. Modest thermogenic and antioxidant effects.

• Dramatically enhances nutrient absorption
• Mild thermogenic properties
• Antioxidant activity

5–20 mg daily, typically combined with other supplements. BioPerine is the most studied branded form.

• GI irritation at high doses
• May alter drug metabolism significantly

Increases bioavailability of many drugs, which can raise risk of adverse effects. Consult prescriber if on medication.

Primarily valuable as a bioenhancer rather than a stand-alone supplement.

• Energy20