Supplement
PQQ (Pyrroloquinoline Quinone)
SavePQQ is a redox cofactor that supports mitochondrial biogenesis and protects neurons from oxidative damage.
Quick verdict
Promising for mitochondrial health and cognitive function in older adults; evidence base is growing but still modest.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Small RCTs show improvements in sleep quality, cognitive function, and markers of inflammation. Animal data strongly supports mitochondrial biogenesis via PGC-1alpha activation.
Benefits
- Promotes mitochondrial biogenesis
- Neuroprotective antioxidant
- May improve sleep quality and cognitive function
Dosage notes
10–20 mg daily. Often combined with CoQ10 for synergistic mitochondrial support.
Side effects
- Headache (uncommon)
- Fatigue at initiation
- Generally well tolerated
Who should be cautious
Generally safe at studied doses. No significant drug interactions identified.
What this page cannot tell you
Human trials are few and small. Optimal dosing and long-term effects remain uncertain.
Leaderboard scores
- Longevity50
- Energy40
- Memory38
- Sleep35
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