Supplement
Pregnenolone
SavePregnenolone is a steroid hormone precursor synthesized from cholesterol, serving as the upstream precursor to DHEA, progesterone, cortisol, and sex hormones.
Quick verdict
Interest in mood and cognitive support, but hormonal downstream effects warrant caution. Clinical evidence is limited.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Small trials in schizophrenia and mood disorders show mixed results. Neurosteroid properties are well characterized. Large-scale safety and efficacy trials are lacking.
Benefits
- Precursor to multiple neurosteroids
- May support memory and mood
- Potential role in stress resilience
Dosage notes
5–50 mg daily in studies. Start low due to hormonal activity. Medical supervision recommended.
Side effects
- Hormonal imbalances
- Acne and oily skin
- Irritability or mood changes
- Insomnia
Who should be cautious
As a hormone precursor, may affect levels of downstream hormones unpredictably. Not recommended without medical supervision.
What this page cannot tell you
OTC availability does not imply safety for unsupervised use. Hormonal cascading effects are complex and individual.
Leaderboard scores
- Mood35
- Memory30
- Stress30
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