Supplement
Punicalagins
SavePunicalagins are ellagitannin polyphenols from pomegranate, responsible for much of its antioxidant activity and metabolized to urolithins by gut bacteria.
Quick verdict
Strong antioxidant capacity in vitro; cardiovascular benefits supported by pomegranate extract trials.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Clinical trials of pomegranate extract (rich in punicalagins) show reduced blood pressure and improved arterial function. Gut conversion to urolithin A varies individually.
Benefits
- Potent antioxidant activity
- Supports cardiovascular health
- Precursor to beneficial urolithins
Dosage notes
Typically consumed as pomegranate extract providing 200–1000 mg punicalagins daily.
Side effects
- GI discomfort
- Potential drug interactions with statins
Who should be cautious
May interact with ACE inhibitors and statins. Pomegranate juice can affect drug metabolism via CYP enzymes.
What this page cannot tell you
Benefits depend on individual gut microbiome capacity to produce urolithins. Isolated punicalagin supplements are less studied than whole pomegranate extract.
Leaderboard scores
- Longevity50
- Immunity35
Write a review
Sign in to write a review.