Supplement
R-Alpha Lipoic Acid
SaveR-alpha lipoic acid is the biologically active enantiomer of alpha-lipoic acid, a potent antioxidant that regenerates other antioxidants and supports glucose metabolism.
Quick verdict
Superior to racemic ALA for bioavailability. Good evidence for diabetic neuropathy and blood sugar support.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Multiple RCTs support alpha-lipoic acid for diabetic neuropathy (600 mg IV). Oral R-ALA has better pharmacokinetics than racemic ALA. Also studied for weight management and heavy metal chelation.
Benefits
- Potent antioxidant that recycles vitamins C and E
- Supports blood sugar regulation
- May improve diabetic neuropathy symptoms
- Both water- and fat-soluble
Dosage notes
100–300 mg R-ALA daily. Stabilized sodium R-lipoate (Na-RALA) preferred. Take on empty stomach.
Side effects
- Hypoglycemia risk in diabetics
- GI discomfort
- Skin rash (rare)
Who should be cautious
May lower blood sugar; monitor if diabetic. Can chelate minerals with long-term use. Possible biotin depletion.
What this page cannot tell you
Stabilized R-ALA (Na-RALA) is preferred as free R-ALA polymerizes easily. Many ALA studies used the racemic form.
Leaderboard scores
- Longevity55
- Pain40
- Energy35
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